A year ago in New York, Dimitrov stopped while trailing 6-3, 6-7 (5), 6-3, 4-1 against Frances Tiafoe in the quarterfinals.
Dimitrov was a semifinalist at the U.S. Open in 2019, at the Australian Open in 2017, and at Wimbledon in 2014.
His highest ranking was No. 3; he is currently No. 21.
With Dimitrov out of the field, Alejandro Tabilo gets a spot in the men's singles bracket, which starts play on Aug. 24.
Brandon Holt is the next player who would move into the draw if another man withdraws. Holt upset Taylor Fritz at Flushing Meadows in 2022 and his mother is two-time U.S. Open champion Tracy Austin.
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AP tennis: https://apnews.com/hub/tennis