The unit will also be under new management after coach Jeff Hafley accepted the job as head coach at Boston College in December.
OSU defensive end Chase Young declared for the draft on Friday.
Prior to this year, 54 Buckeyes have gone pro with eligibility remaining, including six last year.
Thirty of Ohio State’s NFL Draft early entrants have gone in the first round, including Dwayne Haskins and Nick Bosa last year.
Bosa was the eighth Ohio State defensive end drafted in the first round, joining his brother Joey, Cameron Heyward, Vernon Gholston, Will Smith, Alonzo Spellman, Eric Kumerow (uncle to the Bosas) and Jim Houston.