Lewis led the Bengals to seven playoff appearances during his tenure, including five straight trips from 2011-15, but Cincinnati went 0-7 in the postseason.
»RELATED: Social media reacts to end of Lewis era
Lewis, 60, was 131-122-3 with the Bengals.
“The team is very appreciative of all that Marvin has accomplished over the past 16 years,” said Bengals President Mike Brown. “Personally, I am very fond of Marvin and will miss working with him. He is a friend and a colleague, and I thank him for what he has meant to this franchise. But it is time to turn the page and look toward the next chapter for our organization, and we are excited about what the future holds for the team and our fans.”
The team will begin the search for a new coach immediately and expects the process to last several weeks.