For Senzel, it was his seventh home run, his first leading off a game.
Votto, the designated hitter for only the fourth time in his career, was 2 for 13 as a DH, when he followed Senzel’s home run with a duplicate copy, Votto’s sixth of the season.
Those were the runs DeSclafani cherished and protected, giving up one run and four hits over 5 2/3 innings to level his record at 3-3.
The only dent the Tribe put on DeSclafani came in the third when Tyler Naquin led with a double and scored on a pair of ground balls, cutting the margin to 2-1.
Doubles by Jose Iglesias and Jose Peraza in the fifth pushed the Reds in front, 3-1, Eugenio Suarez homered leading off the sixth and Curt Casali homered leading off the seventh for a 5-1 lead.
That gave the Reds four solo home runs and two more runs came across in the eighth on a two-run double by Iglesias.
The Tribe collected only one run and two hits over the last 3 1/3 innings against the Reds bullpen. Amir Garrett pitched 1 1/3 and gave up one hit, Michael Lorenzen pitched an inning and gave up a harmless solo home run to Carlos Santana.
Zach Duke (two outs) and Jared Hughes (one out) combined to close it out in the ninth.
After giving up a run in the second, DeSclafani was in tepid water only one other time and that was in the third when the Indians filled the bases with one out. Naquin hit into an inning-ending double play and that was that for the Tribe.
The Reds made the most of their nine hits to score seven runs. Eight of the Reds’ nine hits were for extra bases.
Only Iglesias with his two doubles had more than one hit. In addition to the four solo home runs and Iglesias’ two doubles, Derek Dietrich had a double and Peraza had a double.
After a seven-game trip during which they were 3-4, the Reds return home Friday night for back-to-back interleague series against the Texas Rangers and Houston Astros.