DeSales QB Reno Godfrey passed for 215 yards and three touchdowns.
Hamilton 31, Oak Hills 21: Keyshawn Stephens ran in a pair of first quarter scores to put Hamilton ahead early, finishing with 170 yards on 22 carries and three touchdowns. Quincy Simms-Marshall was 9-of-12 for 136 yards with one TD and Erik Rios booted a 40-yard field goal.
Colerain 41, Middletown 14: Au'Braylen Million scored on an 85-yard pass from Kamari Fuller and Josh Bryant added a TD run in a losing effort for Middletown.
Badin 41, Purcell Marian 8: Zach Switzer threw two touchdowns, including a fourth down TD pass to Josh Hegemann, to lead Badin. Switzer, Landon Vidourek and Alex DeLong each added a rushing score.
Col. DeSales 42, Fenwick 22: John Maxwell recorded a safety and Colt Bradshaw had a pair of rushing touchdowns in the loss for Fenwick.
New Miami 39, Clark Montessori 6: The host Vikings improved to 5-0 overall and 2-0 in the Miami Valley Conference.
Ross 48, Mount Healthy 30: The Rams (4-1, 1-1) bounced back from their first loss of the season with a big win in SWOC play over the visiting Owls.
Harrison 28, Edgewood 10: Edgewood jumped out to a 10-0 lead in the first quarter, spurred on by a Lincoln Howell 55-yard TD scramble, but Harrison put the game out of reach in the second half.
Little Miami 41, Talawanda 19: The visiting Braves suffered their first loss of the season
Ross 48, Mount Healthy 30: Mekhi Bouldin tallied three touchdowns, including a kickoff return, and Jackson Gifford and C.J. Boze ran for two scores apiece to pace Ross.
Princeton 28, Lakota East 24: The visiting Vikings (3-2, 1-2) handed the Thunderhawks (3-2, 2-1) their first GMC loss of the season.
Valley View 42, Monroe 20: Cade Cradlebaugh tossed three touchdowns in the first half to help Valley View stake a 28-7 lead. Monroe pulled within eight points after a pair of Collin Deaton rushing scores in the third quarter but Cradlebaugh connected with Troy Coulter on two more touchdowns to put the game away. Cradlebaugh finished 11-of-15 for 317 yards and five scores.
Springboro 45, Miamisburg 0: Moise Armbruster tallied 180 yards on 11 attempts with two touchdowns and Timmy Keseday added two rushing scores to help unbeaten 'Boro open conference play with a win. Christian Davis and Ethan Osborne each had five catches for 'Burg.
Milton-Union 30, Madison 21
Brookville 28, Carlisle 10
Wayne 35, Lebanon 21