Firefighters forced the doors open to reach the driver inside, who died at the scene. Investigators identified her as 62-year-old Virginia Faye Rose.
A wrecker was called in to lift the car out of the water and back onto the bridge above.
Those who travel the road often said there have been other serious wrecks there before.
“It’s scary, man. People fly down this road like crazy. Especially right here because it’s narrow,” Croft said.
Troopers they believe Rose was possibly heading to work when the wreck happened.
They said she was not wearing a seatbelt, and speed appears to be a factor in the crash.