UPDATE @ 1:41 a.m.:
Ohio State Highway Patrol troopers have cleared the scene of the crash on Interstate 75 North near state Route 63.
Two vehicles were loaded onto flatbeds and multiple highway patrol units were on scene before it was cleared.
The Ohio State Highway Patrol and several fire/rescue units have been dispatched to I-75 North at the exit to state Route 63 in Monroe for a reported multiple-vehicle accident with multiple injuries.
The incident was reported just after 11 p.m. and the state patrol has shut down the right two lanes because of the accident.
This is the exit to the Cincinnati Premium Outlets mall, which opened at 6 p.m. as part of the long holiday shopping weekend.
News Center 7 will update this developing report as we learn more.