What to know about the conflict between Israel and Iran, and the US intervention

The United States has inserted itself into Israel’s war against Iran, bombing three of the Islamic Republic’s nuclear sites overnight
Shattered rooms are seen in an apartment building at the site of a direct missile strike launched from Iran in Tel Aviv, Israel, Sunday, June 22, 2025. (AP Photo/Oded Balilty

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Shattered rooms are seen in an apartment building at the site of a direct missile strike launched from Iran in Tel Aviv, Israel, Sunday, June 22, 2025. (AP Photo/Oded Balilty

ATHENS, Greece (AP) — The United States inserted itself into Israel's war against Iran, bombing three of the Islamic Republic's key nuclear sites overnight. U.S. President Donald Trump asserted that the sites were “completely and fully obliterated,” and warned there would be additional strikes if Iran retaliates.

The U.S. attacks came after a week of open conflict between Israel and Iran, sparked by Israel's sudden barrage of attacks against Iran's nuclear and military structure.

Israeli strikes began on June 13. Targeting Iranian military and nuclear sites, they killed several top military officials and nuclear scientists. Iran retaliated by firing hundreds of missiles and drones at Israel, some of which penetrated the country's vaunted multi-tiered air defense system. The war so far has killed hundreds of people and wounded more than 1,000 in Iran and killed two dozen and wounded hundreds in Israel.

Iran insists its nuclear program is only for peaceful purposes. But Israel views Iran’s nuclear program as an existential threat and has said its military campaign is necessary to prevent Iran from building an atomic weapon.

Although U.S. intelligence agencies have assessed that Tehran is not actively pursuing a bomb, Trump and Israeli leaders have argued it could quickly assemble a nuclear weapon, making it an imminent threat.

The region has been on edge for the past two years as Israel seeks to annihilate the Hamas militant group, an Iranian ally, in the Gaza Strip, where war still rages after Hamas' Oct. 7, 2023, attack on southern Israel.

Here's what to know about the conflict between Israel and Iran, and the United States' intervention:

U.S. bombs Iran

President Donald Trump announced the overnight "massive precision strikes" on Iran's Fordo, Isfahan and Natanz nuclear sites in a televised address to the nation from the White House. Describing them as "a spectacular military success," he said they had "completely and fully obliterated" the nuclear sites. Iran, he said, would now have to make peace.

Iran's Atomic Energy Organization confirmed the attacks, but insisted its nuclear program will not be stopped. Iran and the U.N. nuclear watchdog agency said there were no immediate signs of radioactive contamination at the three locations following the strikes.

The nuclear fuel enrichment site at Fordo is buried deep beneath a mountain, and the attack against it used bunker-buster bombs designed to penetrate the ground before exploding, a U.S. official said, speaking on condition of anonymity to discuss military operations. Only the United States has the 30,000-pound (13,600-kilogram) munition and the stealth bombers used to deliver them.

Trump warned there would be additional strikes if Tehran retaliated against U.S. forces, while Israeli Prime Minister Benjamin Netanyahu praised Trump’s decision to attack.

Iran's response

Iran launched a barrage of missiles against Israel overnight and into Sunday, with Israeli authorities reporting that more than 80 people were wounded, the vast majority of them lightly.

Iran’s Foreign Minister Abbas Araghchi warned in a post on X Sunday that the U.S. attacks “will have everlasting consequences.”

In a separate post, he said the overnight strikes had scuttled any chance of diplomacy with the U.S. or the European Union.

“Last week, we were in negotiations with the U.S. when Israel decided to blow up that diplomacy. This week, we held talks with the E3/EU when the U.S. decided to blow up that diplomacy,” Araghchi wrote on X. “What conclusion would you draw?”

In a lengthy statement posted Sunday morning, the Iranian Foreign Ministry said that the “U.S. has itself launched a dangerous war against Iran.” It said Iran "reserves its right to resist with full force against U.S. military aggression and the crimes committed by this rogue regime, and to defend Iran’s security and national interests.”

‘A dangerous escalation’

U.N. Secretary-General Antonio Guterres said he was "gravely alarmed" by the United States' use of force, and called the strikes a "dangerous escalation." World leaders issued calls for diplomacy.

"There is a growing risk that this conflict could rapidly get out of control — with catastrophic consequences for civilians, the region and the world," Guterres said in a statement on X. "I call on Member States to de-escalate."

The European Union’s foreign policy chief, Kaja Kallas, said Iran must not be allowed to develop a nuclear weapon, but urged restraint.

“I urge all sides to step back, return to the negotiating table and prevent further escalation,” she said in a social media post. Kallas will chair a meeting of the 27-nation bloc’s foreign ministers in Brussels on Monday, with the Israel-Iran war high on the agenda.

Iranian-backed Houthi rebels in Yemen, who had threatened to resume attacks on U.S. vessels in the Red Sea if the Trump administration joined Israel's military campaign, called on other Muslim nations to form "one front against the Zionist-American arrogance."

Iranian Supreme Leader Ayatollah Ali Khamenei had warned the U.S. on Wednesday that strikes against Iran would “result in irreparable damage for them.”

The Israeli military said Saturday it was preparing for the possibility of a lengthy war, while Iran's foreign minister warned before the U.S. attack that American military involvement "would be very, very dangerous for everyone."

This satellite image provided by Maxar Technologies shows vehicles at the Fordo enrichment facility in Iran on Friday, June 20, 2025. (Maxar Technologies via AP)

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The map above locates the three Iranian nuclear facilities that were bombed by the U.S. on June 21. (AP Graphic)

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President Donald Trump speaks from the East Room of the White House in Washington, Saturday, June 21, 2025, after the U.S. military struck three Iranian nuclear and military sites, directly joining Israel's effort to decapitate the country's nuclear program, as Vice President JD Vance, Secretary of State Marco Rubio and Defense Secretary Pete Hegseth listen. (Carlos Barria/Pool via AP)

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