Labeling Pompeo a "neocon," Paul had said at the time that he would not vote for the CIA chief, worried that Pompeo was too much like the Republican Party that strongly backed with war in Iraq on Saddam Hussein.
"I simply cannot support Pompeo's nomination to be our chief diplomat," the Kentucky Republican made clear.
But after talks with Pompeo and the President, Paul gave in.
The late changes saved the GOP from an embarrassing foreign policy setback for the President - at a time when he is hosting the French President, and will later in the week receive the German Chancellor.
"He is extremely qualified for the position," the President's Press Secretary Sarah Huckabee Sanders argued for Pompeo, as she joined GOP Senators in reminding Democrats of the bipartisan votes for past Secretaries of State.
"John Kerry was confirmed 94-3. Hillary Clinton was confirmed 94-2. Condoleezza Rice was confirmed 85-13. Colin Powell was confirmed unanimously by voice vote," Sanders told reporters.
The turn of events came hours after the President had blasted Democrats for delaying many of his nominees, by stretching out debate time on the Senate floor, leaving little time for work on legislation.
While the President accurately nicked the Democrats for slow-walking many nominations on the Senate floor, certain high-profile choices like Pompeo, Jim Bridenstine for NASA, and Ambassador to Germany Richard Grenell have been held up in the Senate not because of Democrats - but because of a lack of unity among Republicans.
For example, Grenell's nomination was sent to the Senate floor back on January 18. While Democrats did object to action in March, there has been no effort by Senate Republicans to hold a vote - which likely means there aren't fifty votes for his nomination.
When Monday began, that was in question for Pompeo as well, but the support of Paul, Flake, and a handful of Democrats, means the President will get his Secretary of State.
"The President deserves to have a Secretary of State that agrees with him or her, in general, on a foreign policy direction," said Sen. Marco Rubio (R-FL), as he argued for Pompeo's approval.
There was a bit of irony, as Rubio last week had been one of the holdouts on the President choice to run NASA - a reminder, that with a 51-49 advantage in the Senate, and the absence of Sen. John McCain (R-AZ), Republicans can't afford to lose more than one vote on anything in the U.S. Senate.