Cosby, 79, is accused of drugging and assaulting the former Temple University employee in 2004.
WPXI's legal analyst expects that more than the usual 12 jurors and two alternates will be selected because of the extremely high-profile nature of the case. More than 100 potential jurors will be called.
Cosby is expected to be in the courtroom.
Allegheny County officials said last week that they called in additional security and staff to handle the high-profile case.
After the jury is selected, it will be bused across the state to Montgomery County for the trial and sequestered for the duration.
The Associated Press and the Cox Media Group National Content Desk contributed to this report.