Jared E. Coburn, 37, who lives at the home, said he was using the powder to make homemade fireworks, investigators said.
"He tried to explain to us that he was making his own version of a firework," Lake Helen police Chief Mike Walker said. "It was a shock. It was definitely a shock."
Investigators said the TATP will be detonated underground in a nearby field, because the material is too volatile to move and because that method allows for the collection of evidence after detonation.
The Federal Bureau of Investigation and the Bureau of Alcohol, Tobacco, Firearms and Explosives were also called to the incident, which remains under investigation.
Coburn was taken into custody on charges of manufacturing an explosive device. Deputies said he could face additional charges.
No other details were given.