The governor of Puerto Rico, Wanda Vazquez, also tweeted her condolences for the family.
Translated, her tweet reads: "I join the pain of the family of Mrs. Vera Cristina Zabala, widow of our star, Roberto Clemente. Vera worked to ensure that Clemente's legacy will last, pride of all Puerto Ricans. Rest in peace."
So did MLB Commissioner Rob Manfred.
This comes just weeks after she was hospitalized in reportedly delicate health.
Vera Clemente is survived by three sons: Roberto Clemente Jr., Luis Clemente and Roberto Enrique.
The Pirates confirmed the sad news, and owner Bob Nutting released a statement regarding Vera Clemente's death:
"We are deeply saddened to learn of the passing of Vera Clemente, the widow of the great Roberto Clemente and a cherished member of the Pittsburgh Pirates and Major League Baseball family.
"Vera epitomized grace, dignity and strength in the wake of heartbreaking tragedy and loss. Following Roberto's passing, Vera raised their three sons into outstanding men, while also working tirelessly to ensure her and her husband's shared vision of compassion, service and love of others lived on forever.
"Vera was an amazing ambassador for the Pirates organization, our city, the game of baseball and their beloved Puerto Rico. It is with very heavy hearts that we send our condolences to Roberto Jr., Luis, Enrique and the entire Clemente family. May they find comfort in knowing that Vera and Roberto are together once again."