The state-run IRNA news agency quoted the head of emergency services in Karaj, Ahmad Mahdavi, as saying two people were killed and others wounded during the unrest. He did not specify whether the two were protesters or security forces, or provide further details.
IRNA circulated videos and photos on social media showing a police pickup truck that had crashed into a concrete barrier on a highway.
It was not immediately clear what caused the crash, but videos showed protesters hurling rocks at the vehicle and a man firing into it as at least three wounded individuals were inside. The photos showed what appeared to be two lifeless bodies.
The semiofficial Tasnim news agency reported that three policemen were seriously wounded in clashes with protesters. It was not immediately clear it it was referring to the same event. Tasnim also reported that protesters set fire to a police kiosk and van. The semiofficial Fars news agency said a member of Iran's paramilitary Basij force was stabbed to death in Karaj.
Iranian authorities heavily restrict media coverage of the protests and have periodically shut down internet access across the country, making it difficult to confirm details of the unrest.
In a separate development, IRNA reported that masked men shot dead Sajad Shahraki, a cleric in the southeastern city of Zahedan, which has seen the deadliest violence in recent weeks. The report did not identify a motive or provide further details.
The nationwide demonstrations were ignited by the Sept. 16 death of 22-year-old Mahsa Amini, who had been detained by the morality police for allegedly violating Iran's strict dress code for women. Authorities say she died because of a health condition and was not mistreated, but her family has cast doubt on that account and the protesters accuse the police of beating her to death.
The first big protests erupted at Amini's funeral in her hometown in the Kurdish region of Iran. The near-daily demonstrations continued, flaring up again 40 days after she was buried.
The protests were initially focused on Iran's enforcement of the Islamic headscarf, or hijab, with crowds of young women removing theirs during raucous street protests. The demonstrations rapidly grew into calls for the overthrow of the theocracy that has ruled Iran for more than four decades.
Security forces have sought to quash dissent, killing at least 300 people and arresting more than 14,000, according to the group Human Rights Activists in Iran, which has been tracking the violence since the protests began. It says at least 36 security forces have been killed.
Iran's judiciary has said more than a thousand people who had a central role in the protests would be brought to trial in Tehran over their "subversive actions," including assaulting security guards and torching public property. Authorities have announced charges against hundreds of people in other Iranian provinces, some accused of "corruption on earth" and "war against God," offenses that carry the death penalty.