Liggins, Offerd, Thomas, and Smart were arrested Wednesday morning, and Roberson was already in custody in Cook County Jail, according to the release.
The federal murder count carries a mandatory minimum sentence of life in prison and a maximum sentence of the death penalty.
Investigators have said for years that most killings in Chicago have tie to gang conflicts, which sometimes begin as online beefs that spill into real world violence. Arresting suspects in gang killings can be especially difficult because witnesses are reluctant to come forward.
At news conference with other law enforcement leaders Wednesday, Chicago Police Superintendent David Brown said the new indictment sends a message that “we are going after gangs in this city.”
“If this gives pause to them then we’re doing something good,” said Chicago-based U.S. Attorney John Lausch, speaking alongside Brown.