Seal's criticism was met with praise, but others seemed to consider the singer a hypocrite, including model and cookbook author Chrissy Teigen.
"Hmm. Let's just say we've all heard things about each other, haven't we?" she commented, according to Entertainment Weekly.
Another person took to Twitter and shared photos of Seal with Kevin Spacey, who has also faced multiple allegations of sexual misconduct, and Seal's ex-wife and mother of his children, model Heidi Klum, posing with Weinstein.
Seal isn't the only public figure who doesn't think Winfrey would make a great president. Actress and comedian Roseanne Barr told reporters she thought she would make a better president than Winfrey during a press tour for the upcoming reboot of her sitcom, "Roseanne."
“I do love Oprah. Of course, I love Oprah like everybody else. But you know what? I think it was time for us as a country to shake things up and, you know, try something different,” Barr said. “Actually, I think I’d be a better president than Oprah and Susan Sarandon, probably even President Trump. And I did run in 2012.”
In her speech, Winfrey called out perpetrators of sexual misconduct and harassment in Hollywood saying, "Their time is up!"
Singer Seal (L) has criticized Oprah for being "part of the problem" in Hollywood in an Instagram post that shows her with movie producer Harvey Weinstein. Weinstein faces accusations of rape and sexual misconduct.
Soon after the awards show, many fans and celebrities, including Meryl Streep, called for Winfrey to try for the Oval Office in 2020.
"She launched a rocket tonight. I want her to run for president. I don't think she had any intention (of declaring), but now she doesn't have a choice," Streep told The Washington Post on Sunday night.
Winfrey's best friend and morning TV anchor, Gayle King, said the speech was not meant to be political, and that she isn't considering running, People reported.
“She did not want it to be a political speech,” King said. “She wanted it to be a uniting speech.”