Sheldon, however, does not react well to the news, telling Penny (Kaley Cuoco) "All this change is just too much.”
The biggest change comes when Penny tells her husband Leonard (Johnny Galecki) she is pregnant.
They decide to tell Sheldon, who, in his self-centered character portrayal frets he is going to get sick, “ruining the greatest day of my life.”
“I promise you you’re not going to get what she has,” Leonard tells Sheldon, who is told about Penny’s pregnancy.
“You’re right, I can’t catch that,” Sheldon said.
The show also featured a cameo by Sarah Michelle Gellar. Raj (Kunal Nayyar) believes he is sitting next to Buffy the Vampire Slayer on the plane, CNN reported.
Sheldon wraps up the finale with a humble speech at the Nobel ceremony, telling the audience "I apologize if I haven't been the friend you deserve, but I want you to know, in my way, I love you all," he says.
The comedy premiered Sept. 24, 2007, and is the longest-running multi-cam comedy of all time, Variety reported. The show has won 10 Emmy Awards and 52 nominations and was nominated for a Golden Globe seven times, the website reported.
"It feels not like a finale so much as a transition. Life goes on," Chuck Lorre, the show's co-creator, told Variety. "We're leaving them, they're not leaving us. We're not blowing the show up at the end. We're just moving away," said Lorre.