Jacksonville, Florida, officers say a man was high on "loveboat" when he shot and killed a driver on I-95.
Police said 32-year-old Tyrell Brown was sleeping in the passenger seat of 25-year-old Steven Shawn Grady's car as they drove through Jacksonville on Sunday.
The group was traveling from Orlando to North Carolina.
At one point, Brown woke up and shot Grady in the face, a witness told police.
The witness, who was in the backseat of the car, tried to gain control of the wheel. The car ran off the interstate and crashed near the Union Street exit around 3:15 a.m.
Officials said Brown violently resisted officers when they got to the scene.
There was no indication of a prior altercation between Brown and Grady, officers said.
A Jacksonville Sheriff's Office spokesperson said Brown smoked a cigarette dipped in formaldehyde and marijuana before the shooting.
He was taken to UF Health Jacksonville for his safety, officers said.
Brown is facing a murder charge. His next court date is Dec. 12.